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Mario Capecchi

AKA Mario Renato Capecchi

Born: 6-Oct-1937
Birthplace: Verona, Italy

Gender: Male
Religion: Quaker
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Scientist

Nationality: United States
Executive summary: Knock-out mice

As a child, Mario Capecchi spent ages 3 through 7 homeless and unattended, living on the streets after Nazis seized and imprisoned his mother. They were reunited after World War II, but his mother's mental health had been shattered, and she never recovered. Capecchi was brought to America and raised by relatives in Pennsylvania, who immersed him in school at the age of 9 despite his inability to read, write, or speak English. He grew up to become a biophysicist, best known for his groundbreaking work in gene targeting in mouse embryo-derived stem cells.

Capecchi was awarded the Nobel Prize in Medicine in 2007. His work involves finding ways to manipulate the mammalian genome by inserting new genes into cells, and has led to the breeding of "knock-out mice" and "knock-in mice" -- animals with a single gene removed or inserted. Dr. Capecchi's Nobel honors were shared with Martin Evans and Oliver Smithies.

Father: Luciano Capecchi (military officer)
Mother: Lucy Dodd-Ramberg Capecchi (poet, d. 1989)
Wife: Laurie Fraser
Daughter: Misha

    High School: George School, Newtown, PA (1955)
    University: BS Chemistry and Physics, Antioch College (1961)
    University: PhD Biophysics, Harvard University (1967)
    Scholar: Harvard University (1967-69)
    Theological: Biochemistry, Harvard University (1969-71)
    Professor: Biology, University of Utah (1973-)

    Kyoto Prize 1996
    National Medal of Science 2001
    Lasker Award 2001 (with Martin Evans and Oliver Smithies)
    Wolf Prize in Medicine 2003 (with Ralph L. Brinster and Oliver Smithies)
    Nobel Prize for Medicine 2007 (with Martin Evans and Oliver Smithies)
    American Association for the Advancement of Science
    American Society for Microbiology
    European Academy of Sciences
    Genetics Society of America
    Howard Hughes Medical Institute Investigator (1988-)
    National Academy of Sciences
    Naturalized US Citizen

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