An explosion occurs at an alternative energy research center; bumbling Det. Frank Drebin is assigned to the case and discovers a deeper conspiracy masterminded by a sociopath industrialist to kidnap presidential energy adviser Prof. Mainheimer. Making matters worse, Drebin's ex, Jane, is deeply entangled. Fast-paced slapstick, plot relatively unimportant. Very funny sequel and worthy successor to The Naked Gun: From the Files of Police Squad! (1988).
| Leslie Nielsen | ... Lt. Frank Drebin |
| Priscilla Presley | ... Jane Spencer |
| George Kennedy | ... Ed Hocken |
| O. J. Simpson | ... Nordberg |
| Robert Goulet | ... Quentin Hapsburg |
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| Richard Griffiths | ... Dr. Meinheimer |
| Richard Griffiths | ... Earl Hacker |
| Anthony James | ... Hector Savage |
| Jacqueline Brookes | ... Commissioner Brumford |
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| Lloyd Bochner | ... Baggett |
| Tim O'Connor | ... Fenzwick |
| Peter Mark Richman | ... Dunwell |
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| Ed Williams | ... Ted Olsen |
| John Roarke | ... George Bush |
| Margery Ross | ... Barbara Bush |
| Peter Van Norden | ... John Sununu |
| Gail Neely | ... Winnie Mandela |
| Colleen Fitzpatrick | ... Blues Singer |
| Sally Rosenblatt | ... Mrs. Redmond |
| Alexander Folk | ... Crackhouse Cop |
| Jose Gonzales-Gonzales | ... Mariachi |
| Larry McCormick | ... TV Reporter |
| Cliff Bemis | ... Barbecue Dad |
| D. D. Howard | ... Barbecue Mom |
| William Woodson | ... TV Commercial Announcer |
| Mel Tormé | ... Himself |
| Zsa Zsa Gabor | ... Herself |
| Bill Chemerka | ... "Ladies and Gentlemen, the President of the United States" |
| Christopher J. Keene | ... "Hey Ken, Al! Look what I found." |
| Ken Kerman | ... "Hey, that's a pretty nice clock." |
| Al Fann | ... "It's 4 minutes too slow." |
| Tom McGreevey | ... "Very well, sir. It's from the lady." |
| James Gilstrap | ... "Always nice to see nice people." |
| Weird Al Yankovic | ... "You pigs... say your prayers." |
| Gina Mastrogiacomo | ... "Is this some kind of bust?" |
| Jeff Wright | ... "Frank, we got that Sure-Grip suck machine?" |
| C. Lindsay Workman | ... "Your coat, sir?" |
| John Stevens | ... "Phone call, commissioner." |
| Datta V. Gokhale | ... "Hey, what the hell happened to the water pressure?" |
| Charlotte Zucker | ... "For a man in a wheelchair, he gets around marvelously." |
| Don Pugsley | ... "He's wired!" |
| Carlos Betancourt | ... "¡Ojala que se mejore pronto!" |
| Bernardo Marquez | ... "Recuerdos a todos." |
| Margarito Mendoza | ... "¡Puede decirme donde esta la casa de musica!" |
| Lee Terri | ... "Hey, look what he's doing to that man in the wheelchair!" |
| Claude Jay McLin | ... "Yeah!" |
| Manny Perry | ... "Let's get him." |
| Alex Zimmerman | ... "Yeah!" |
| Raynor Scheine | ... "You're on my groin." |
| John Fleck | ... "If that's your attitude, forget it." |
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| People who didn't have lines, but we like 'em |
| Susan Breslau | ... Party Guest |
| Leslie Maier | ... Party Guest |
| Ron Rosenblatt, D.D.S. | ... Mr. Redmond |
| Jennifer Kretchmer | ... Barbecue Girl |
| Ryan Harrison | ... Barbecue Boy |
| David Zucker | ... Davy Crockett |
| Robert Weil | ... George Russell |
| Robert K. Weiss | ... Obstetrician |
| Robert LoCash | ... FBI Agent |
| Burton Zucker | ... Lab Technician |
| Lewis Friedman | ... Lab Technician |
| Bob Reitman | ... Lab Technician |
| Gene Mueller | ... Lab Technician |
| Gino Salomone | ... Lab Technician |
| Robert J. Elisberg | ... McTigue |
| Mindy Newborn | ... Slave to the Composer |
| Jan Campbell | ... Lady in Waiting |
| Wendy Hogan | ... Lady in Waiting |
