| Billy Crudup | ... Fielding Pierce |
| Jennifer Connelly | ... Sarah Williams |
| Molly Parker | ... Juliet Beck |
| Janet McTeer | ... Caroline Pierce |
| Paul Hipp | ... Danny Pierce |
| Sandra Oh | ... Kim |
|
| John Carroll Lynch | ... Fr. Mileski |
| Stanley Anderson | ... Fielding's Father |
|
| and |
| Hal Holbrook | ... Isaac Green |
|
| Bill Haugland | ... TV Newsman at Bombing |
| Nelson Landrieu | ... Francisco Higgens |
| Ivonne Coll | ... Gisela Higgens |
| Maxine Guess | ... Danny's Receptionist |
| Lawrence Dane | ... Gov. Kinosis |
| Ed Harris | ... Jerry Charmichael |
| Robert Harding | ... TV Newsman #2 |
| Larry Marshall | ... Angelo Bertelli |
| Don Jordan | ... Minister with Bertelli on TV |
| Caroline Sabourin | ... Little Sarah Look-Alike |
| Patricia Gage | ... Fielding's Mother |
| Bruce Dinsmore | ... Tony Dayton |
| Mimi Kuzyk | ... Adele Green |
| Tony Calabretta | ... Sonny Marchi |
| Walter Massey | ... Otto Ellis |
| Norris Domingue | ... Congressman at Isaac's Party |
| Dean Hagopian | ... Politician at Isaac's Party |
| Bernard Behrens | ... Fr. Stanton |
| Philip Williams | ... Al |
| Sharon Washington | ... Kelly |
| Ranee Lee | ... Woman from Fielding's Campaign |
| Zoë Sakellaropoulo | ... "Sarah" in Caroline's Flashback |
| Scott Spencer | ... Man with Sarah in Flashback |
| Alan Fawcett | ... Reporter at Restaurant |
| Leah Pinsent | ... Reporter from Fielding's Past |
| Karina Iraola | ... Seny |
| Marco Ledezma | ... Gustavo |
| Walt MacPherson | ... Sarah's Father |
| Fr. John Walsh | ... Protest Leader Outside Sarah's Funeral |
| Vlasta Vrana | ... Priest at Sarah's Funeral |
| Pascal Petardi | ... Kid who Mugs Fielding |
| Leonardo Fuica | ... Kid who Mugs Fielding |
| Qariy Hendrickson | ... Kid who Mugs Fielding |
| Sandra Caldwell | ... Concerned Mom from Letter |
| Justin Bradley | ... Adopted Kid from Letter |
| Richard Hicks | ... Young Man from Letter |
| Ed Cambridge | ... Old Man from Letter |
